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However, due to the irreversibility of the overall reaction catalyzed by the multienzyme complex, it acts as a one-way bridge : pyruvate can be decarboxylated and oxidized, and the remaining acetyl unit can be linked to CoA, but the reverse reaction, conversion of acetyl-CoA to pyruvate, is not possible

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The enhancement of cognitive function is linked to changes in the kynurenine pathway within the DLPFC, affecting the interaction between the mGluR2 and 5-HT2A receptors and helping to prevent early stages of psychosis [27, 140]

The mixture was vortexed and heated at 50 C for 15 min, then cooled and mixed thoroughly