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[DOI] [PMC free article] [PubMed] [Google Scholar] 158.McMillan JM, Walle UK, Walle T

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Specifically, -syn pathology not only directly impairs mitochondrial function and activates neuroinflammation, but its own aggregation process is also markedly promoted by OS and inflammatory environments [46]

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In addition, commercially available products may present other limitations : Fixed dosing that does not allow for gradual titration Lack of preservative-free or dye-free options Absence of certain medications in oral form in the United States Limited flexibility in combining therapies to match multisystem symptom patterns In many MCAS cases, therapies cannot be fully implemented using commercially manufactured products alone