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Pharmacological inhibition of GPX4 accelerates motor neuron degeneration and death (366, 367, 369), whereas GPX4 overexpression delays disease onset, improves motor function, and prolongs survival (368, 371)

Touyz RM, Anagnostopoulou A, Rios F et al (2019) NOX5: Molecular biology and pathophysiology

Most therapeutic peptides are stable in the 4.5-7.0 range

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One aspect of this study that may be missed are the overall excellent responses achieved with only a moderate dose of methotrexate, highlighting the potency of methotrexate as a DMARD which can often be overlooked in clinical trials that typically enroll only subjects with inadequate responses to methotrexate