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For example, reduced activity of the antioxidant enzyme GPx4 fails to suppress intracellular ROS production, resulting in lipid peroxidation (116)

[DOI] [PMC free article] [PubMed] [Google Scholar] 21.El-Masri BM, Leka B, Mustapha F, Gundesen MT, Hinge M, Lund T, et al

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Updated Results for Bortezomib (BTZ)-nave Patients (Pts) Enrolled in PX-171-004, an Ongoing Open-label, Phase (Ph) 2 Study of Carfilzomib (CFZ), in Relapsed Multiple Myeloma