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By promoting immune remodeling that mirrors and potentially accelerates immunosenescence, smoking may shape susceptibility to MS, hasten the transition from relapsing inflammatory activity to progressive neurodegeneration, and reduce the effectiveness of existing therapies

research questions are set by funding and publishing considerations instead of open, honest inquiry

Every member of the test was told to be as honest and impartial as they can, which they took onboard and it delivered some interesting results

Notably, the crude association for former smokers was substantially stronger (crude OR 1.59), indicating that the higher unadjusted prevalence in this group was largely explained by age and other confounders rather than by smoking history alone

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