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Am J Cancer Res (2022) 12(7):334756

Mediation of metabolism LRP8 LRP8 modulates cancer ferroptosis by regulating selenocysteine levels, which are required for translation of the selenoprotein GPX4

In addition, metformin activated p-AMPK and promoted the translocation of Pink1 from the cytoplasm to mitochondria, thereby promoting the occurrence of mitophagy in HK-2 cells under HG/HFA ambience (141)

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