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10.1080/13813450701661198 Arch Physiol Biochem

doi:10.1021/bi00171a002

Among surviving patients, the most severely affected patients have intellectual disability, progressive cerebellar disease and ataxia, recurrent bacterial infections, and chronic metabolic acidosis and hemolytic anemia

In addition, mitochondria are also the primary producers of intracellular reactive oxygen species (ROS), most of which originate from the mitochondrial respiratory chain [55]