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Other considerations documented for tirzepatide in its FDA labeling include injection-site reactions, decreased appetite, and warnings such as the risk of thyroid C-cell tumors observed in rodents (a boxed warning) and pancreatitis and gallbladder events

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J Neurosci 35(2):807 Church FC (2021) Treatment options for motor and non-motor symptoms of Parkinsons disease

By dampening NMDA activity, DSIP reduces the mental hyperarousal that keeps you awake despite physical exhaustion