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A study showed that probiotic-fermented Pueraria lobata (Willd.) Ohwi significantly reduced the abundance of Bacteroidetes and Akkermansia muciniphila while increasing the abundance of Firmicutes and Lactobacillus , which modulated aberrant gut microbiota composition and activated nuclear transcription factor (erythroid-derived 2)-like 2 (Nrf2)-mediated signals, thereby improving lipid accumulation and inflammation and exerting antioxidant effects and ultimately preventing ALD ( in vivo and in vitro , which is inseparable from its impact on the gut microbiota ( Table 1 Research overview of TCMs and NPs targeting gut microbiota for liver disease therapy

49 On the contrary, high iron content in cells will reduce iron intake and increase iron storage by releasing of IRP1/2 from IRE of TfR1 and ferritin

Meili-Butz, S., Niermann, T., Fasler-Kan, E., Barbosa, V., Butz, N., John, D., et al

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Human CBS was cloned into pcDNA5-FRT encoding for a C-terminal Flag-mKO2-tag for the mammalian expression vectors