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3 If the product of a Phase I reaction is not soluble enough to be excreted, a Phase II conjugation reaction will typically accomplish this

Bemmaor, J

doi: 10.1016/j.numecd.2013.04.016 137 MinozziMCostantinoDGuaraldiCUnferV

While eNOS activation at optimal levels of BH 4 leads to production of NO, activation of NOS in the absence of or in the presence of decreased levels of BH 4 results in generation of superoxide rather than NO in the vascular endothelium