Disclosures: Isaac Israel Rodriguez Salazar: Nothing to Disclose, Andreas Teufel: Nothing to Disclose, Abhinay Vellala: Nothing to Disclose, Timo Itzel: Nothing to Disclose, Jimmy Daza: Nothing to Disclose, Michael Vcha: Nothing to Disclose, Manuel Debic: Nothing to Disclose, De-Hua Chang: Nothing to Disclose, Michael Dill: Nothing to Disclose, Max Seidensticker: Nothing to Disclose, Gerd Oswald Stefan Schnberg: Nothing to Disclose, Lukas Mller: Nothing to Disclose, Julia Mayerle: Nothing to Disclose, Stefan Munker: Nothing to Disclose, Peter Galle: Bayer: Consultant, Roche: Advisor, Eisai: Advisor, AstraZeneca: Advisor, BMS: Advisor, MSD: Advisor, Guerbet: Advisor, Arndt Weinmann: Servier: Advisor, Abbview: Speaking and Teaching, AstraZeneca: Speaking and Teaching, Incyte: Advisor, Taiho: Advisor, Roche: Speaking and Teaching, Dietmar Tamandl: Nothing to Disclose, Matthias Pinter: BMS: Consultant, AstraZeneca: Consultant, Eisai: Consultant, Ipsen: Speaking and Teaching, Roche: Consultant, MSD: Speaking and Teaching, Marino Venerito: Nothing to Disclose, Matthias Ebert: Nothing to Disclose, Matthias Froelich: Nothing to Disclose, Maciej Pech: Nothing to Disclose, Friedrich Sinner: Nothing to Disclose, Bernhard Scheiner: Nothing to Disclose 1876 SPATIAL OMICS ANALYSIS OF THE PROXIMITY OF PD-L1(+) TUMOR-ASSOCIATED MACROPHAGE AND CD8T CELL INTERACTION PROMOTING HEPATOCELLULAR CARCINOMA PROGRESSION Takuto Nosaka 1 Masahiro Ohtani 1 Junki Yamashita 1 Yosuke Murata 1 Tomoko Tanaka 1 Yu Akazawa 1 Kazuto Takahashi 1 Tatsushi Naito 1 Yasunari Nakamoto 1 , 1 University of Fukui Background: Spatial omics technology enables visualization of the tumor immune microenvironment and analysis of immune cell interactions
This hypothesized proteolytic knockdown of components of both the thioredoxin and glutaredoxin systems is consistent with a viral strategy to inhibit DNA synthesis, to increase the pool of ribonucleotides for RNA synthesis, thereby enhancing virion production
doi: 10.1039/D1OB01992A 121 ZardastMNamakinKKahoJEHashemiSS
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