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Molecular determinants and genetic modifiers of aggregation and toxicity for the ALS disease protein FUS/TLS

HP 13 C MR via dissolution dynamic nuclear polarization (dDNP) is an emerging imaging technology that allows direct visualization of metabolic conversion of 13 C-enriched molecules, and has been applied extensively to study metabolism in cells, tissues, animal models, and patients 22,23,24

Neurogenesis in aging and age-related neurodegenerative diseases

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For example, urine metabolomics analysis revealed that metabolites associated with the ferroptosis signaling pathway were uniquely expressed in patients with diabetic nephropathy, indicating that ferroptosis could be a key mechanism in disease progression [80]