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To minimise the potential impact of changes in smoking behaviour and higher mortality in those with baseline illness (also known as reverse causality or the sick quitter effect), participants with a self-reported history of doctor-diagnosed cancer other than melanoma and/or non-melanoma skin cancer (n = 30,393, 11%) and those with a history of cardiovascular disease at baseline, defined as self-reported doctor-diagnosed heart disease, stroke, or blood clot on the baseline questionnaire (n = 30,548, 11%) were excluded from this study

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