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Modulators of hepatic energy, metabolic, lipid homeostasis, immune and inflammatory response (PPARA, RXRA, PXR) have a significantly higher expression in GF-HLCs and PHHs in comparison to SM-HLCs (Figure 2F)

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Upregulation of autophagy-related proteins (including BCL-1, ATG7, ATG5, and LC3-II) in synovial tissues contributes to synovial fibroblast proliferation, resistance to apoptosis, and chronic inflammatory activation

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