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Immune hemolytic anemia Result of an immune event that occurs on the surface of the erythrocyte Direct: Action of an antibody on the membrane with or without complement Indirect: an immune complex that is adsorbed on the erythrocyte and fixes complement, which is generated by its lysis by the action of macrophages Autoimmune hemolytic anemia Autoantibodies The direct antiglobulin test, better known as direct Coombs, demonstrates the presence of antibodies or complement on the surface of the red blood cell and is a cornerstone in the diagnosis of autoimmune hemolytic anemia

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J Neurosci 42:31333149