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An increase in body temperature is a signal to activate the expression of heat shock proteins (HSP) which constitutively function as molecular chaperones maintaining the native structure of the proteins

Structurally, it is a tripeptide

Regulatory and Approval Reality Regulatory status is a hard fact that does not depend on mechanistic promise, so it is worth stating plainly

In contrast, Tregs are not subject to this restriction

* Correspondence: Haixia Zhou, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers