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Hypoxia induces mitochondrial protein lactylation to limit oxidative phosphorylation

The key is ensuring that both are present in the system so they can participate in the redox recycling cycle

10.3389/froh.2024.1461022 3 BeizaeiK.GleinerL.HofferK.BumannL.VuA

The mechanisms of ferroptosis discovered in age-related cataracts, including iron dysregulation, ROS accumulation, and impaired antioxidant defenses, are likely to be involved in the development of radiation-induced cataracts

The side chain of axin Leu392 is buried in a hydrophobic pocket formed by the side chains of Val263, Leu266, Val267 and Ile270 from the hydrophobic helix (262273) on one side, and Phe293 from the extended loop in GSK3 on the other side