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More information can be found in the article: Vitamin B12 Deficiency and Anesthesia Conclusion: Vitamin B12 and Nerves In the research into vitamin B12, nerve health is one of the central topics

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T4 is basically inert and needs to be converted in the liver, into T3 the active hormone that is the body's fuel and kick starts metabolism

Patients with severe kidney disease or end-stage renal disease may not be appropriate candidates for this therapy, particularly if they have significant fluid retention or are prone to dehydration