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viii Lang C, et al

This sharp decline is considered a key biological event contributing to affective instability and cognitive impairment during the menopausal transition (52,53)

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Polymeric nanoparticles, such as those generated from polylactic-co-glycolic acid (PLGA) or polyethylenimine (PEI), also appear promising, as these materials can be tailored to deliver siRNA precisely to microglia or neurons while allowing for prolonged release (96)