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Overdose reactive intermediates/reactive metabolites are also liable to covalently bind to cellular proteins or DNA (Yan et al., 2008), and eventually initiate and trigger a series of toxic effects, including protein abnormal modification, enzyme inactivation, DNA crosslink, formation of immunogenic species, cell death, or oncogene activation, organ injury ( The present review focuses on the toxicity of natural products, analyzing the key role of metabolic activation in their toxicities

In conclusion, the complex relationship between the gut microbiota and ferroptosis emphasizes the importance of maintaining a healthy microbiota for host health

3-Year follow-up of temporary implantable nitinol device implantation for the treatment of benign prostatic obstruction

Br J Nutr (2011) 105:1798807

Pressures of 20 and 30 MPa were chosen to simulate conditions in the upper ocean of Europa