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High-dose ferric ammonium citrate (FeAC) triggers MM cell death with concurrent elevation of MDA - a lipid peroxidation byproduct and hallmark of ferroptosis, establishing iron metabolism as a critical modulator in MM pathophysiology ( 6.3 Oxidative stress pathway Emerging evidence demonstrates that andrographolide, a natural bioactive compound, induces ferroptosis in MM cells via P38-mediated suppression of the Nrf2/heme oxygenase-1 (HO-1) signaling axis, thereby triggering oxidative stress ( 6.4 Autophagy pathway Beclin-1, a core autophagy-related protein, drives autophagosome formation, while UNC-51 like kinase 1 (ULK1) coordinates autophagic initiation through its kinase complex (Zhong et al., 2020)