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Description

Front Oncol (2021) 11:647559

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Pyruvate goes to TCA cycle, from where -ketoglutarate is produced, which is then, converted to glutamine and ultimately leads to formation of proline 59,60

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It is an ion Channel that consists of 6 transmembrane regions and belongs to the transient receptor potential (TRP) family (Gunthorpe et al., 2002)

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Triggers include genetic susceptibility (HLA-DR3/DR4) and environmental factors (viral infections, gut microbiome alterations)

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Clin J Am Soc Nephrol 7:11121120

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