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In contrast, Probiotic effects are dose-dependent, with typical effective doses ranging from 10 8 to 10 11 colony-forming units per day in animal studies (95)

and second, therapeutic peptides that are rationally designed to address traditional limitations of peptide-based agents, including proteolytic degradation and challenges related to stability, bioavailability, and delivery

Furthermore, the hepatoprotective properties of safflower may be attributed to polyphenols such as quercetin, chlorogenic acid, and HSYAs ability to augment the synthesis of hepatic antioxidative enzymes that regulate obesity

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doi: 10.1038/ncb1101-1009 37 HakunoFTakahashiSI