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Similarly, oral administration of either glutathione or other low-molecular-weight thiols (eg, 2-mercaptopropionylglycine or N-acetyl cysteine) to these patients neither substantially raises intracellular glutathione levels nor alters their acid-base balance or excretion of 5-oxoproline (71

Acknowledgements We are grateful to the animal facility staff at Beth Israel Deaconess Medical Center (BIDMC) for assistance with in vivo experimentation

Delitto A, George SZ, Van Dillen LR, et al

Hypertension-induced cardiomyocyte hypertrophy is closely linked to adverse cardiac events (181, 182)