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Therefore, the results from the FAERS database should be interpreted with caution as they can overestimate adverse events due to reporting bias and do not establish causality

As illustrated in Figure 4, the gut microbiota serves as a central hub in diabetic lung injury, where gut-derived metabolites and toxins (e.g., LPS, BCAAs) remotely regulate pulmonary inflammation and immune responses through systemic circulation, ultimately leading to endothelial disruption and oxidative stress

doi: 10.1038/s41590-023-01601-2 36 SteinSRRamelliSCGrazioliAChungJ-YSinghMYindaCKet al

Conclusion In conclusion, our in vivo studies indicate that LPS-induced memory impairment can be attenuated by the mitochondrion-targeted antioxidant elamipretide