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Description

Venous insufficiency is partly a collagen deficiency disease

We next investigated whether Gsta4 over-expression could work as a model for decrease in intracellular 4-HNE load, resulting in fewer biomolecules being covalently modified by 4-HNE

It is typically a convergence of nutrient depletion, toxic overload, gut dysfunction, and genetic susceptibility that collapses multiple pathways simultaneously