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Absence of hemolytic effects of L-DOPA on transfused G6PD-deficient erythrocytes

Czimmerer, Z

Lastly, in contrast to GLO1, we found GLO2 protein levels to be downregulated and its precursor sLG to be upregulated by hypoxia in lung cancer cells, suggesting that hypoxic cells need to detoxify MG either by alternative routes 47,70 or perhaps they rather accumulate the nontoxic intermediate sLG than producing higher levels of D-lactate, which would further increase acidification next to the already upregulated anaerobic L-lactate production from pyruvate

Infection and Drug Resistance, pp 15851599

Additionally, MDM2-independent ubiquitination regulates p53 activity by influencing cell degradation and localization