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1 Introduction Glioblastoma (GBM) is the most common primary brain tumor, exhibiting highly mortality rate due to its aggressiveness and invasiveness (Wirsching et al., 2016)

The dark roast measured higher concentration of N-methylpyridinium 87 mg/l compared to the medium roast (29 mg/l), but lower trigonelline and CGA (Rubach, 2014)

Herpetic whitlow is a painful viral cutaneous infection that usually affects the distal fingers or thumbs, and occasionally the toes

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Vitamin B12 and Metformin The diabetes medicine, metformin, interferes with B12 absorption in the intestine by impeding the calcium-dependent intake mechanism